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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTGES All Species: 20
Human Site: Y58 Identified Species: 55
UniProt: O14684 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14684 NP_004869.1 152 17102 Y58 L R H G G P Q Y C R S D P D V
Chimpanzee Pan troglodytes XP_528441 152 17073 Y58 L R H G G P Q Y C R S D P D V
Rhesus Macaque Macaca mulatta XP_001107574 152 17098 Y58 L R H G G P Q Y C R S D P D V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9JM51 153 17267 Y59 L K R G G L Q Y Y R S D P D V
Rat Rattus norvegicus P08011 155 17453 F62 K G E N A K K F L R T D E K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415475 146 16623 Y52 L R N G G L Q Y Y R E D P D V
Frog Xenopus laevis NP_001086699 145 16911 Y51 L R H G G I Q Y Y R Q D P D V
Zebra Danio Brachydanio rerio NP_001014828 146 16439 F52 E R H G G V Q F C R T D P Y V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_788903 167 18680 V72 R L S R S T E V R F G D P N V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98 98 N.A. N.A. 79 36.7 N.A. N.A. 68.4 60.5 61.1 N.A. 33.5 N.A. N.A. N.A.
Protein Similarity: 100 98.6 98.6 N.A. N.A. 83.6 54.8 N.A. N.A. 78.2 73 73 N.A. 53.2 N.A. N.A. N.A.
P-Site Identity: 100 100 100 N.A. N.A. 73.3 20 N.A. N.A. 73.3 80 66.6 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 N.A. N.A. 80 40 N.A. N.A. 80 80 80 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 45 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 100 0 67 0 % D
% Glu: 12 0 12 0 0 0 12 0 0 0 12 0 12 0 0 % E
% Phe: 0 0 0 0 0 0 0 23 0 12 0 0 0 0 0 % F
% Gly: 0 12 0 78 78 0 0 0 0 0 12 0 0 0 0 % G
% His: 0 0 56 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % I
% Lys: 12 12 0 0 0 12 12 0 0 0 0 0 0 12 0 % K
% Leu: 67 12 0 0 0 23 0 0 12 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 12 12 0 0 0 0 0 0 0 0 0 12 0 % N
% Pro: 0 0 0 0 0 34 0 0 0 0 0 0 89 0 0 % P
% Gln: 0 0 0 0 0 0 78 0 0 0 12 0 0 0 0 % Q
% Arg: 12 67 12 12 0 0 0 0 12 89 0 0 0 0 0 % R
% Ser: 0 0 12 0 12 0 0 0 0 0 45 0 0 0 0 % S
% Thr: 0 0 0 0 0 12 0 0 0 0 23 0 0 0 0 % T
% Val: 0 0 0 0 0 12 0 12 0 0 0 0 0 0 100 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 67 34 0 0 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _